Enhanced Solubility of Meloxicam with Sodium Benzoate Hydrotrope: Ecofriendly Approach for Improved Topical Drug Delivery

Abstract: Background: Hydrotropic solid dispersion has been reported as a potential process to improve the poor solubility of drugs using conventional hydrotropes. The presented investigation described water-soluble hydrotropic system for Meloxicam (MX) sodium benzoate hydrotrope enhance and topical delivery. Thus, was prepared, characterized, converted into HSD-Meloxicam gel. prepared gel further characterized in vitro performance. Material Methods: Solid by solvent evaporation method 1:4 ratios. systems were in-vitro release drug content. Accordingly, rate-controlling polymer penetration enhancers selected formulated hydrogel bases. evaluated performance parameters like content, pH, viscosity, spreadability, kinetics, diffusion study, accelerated stability studies, viscosity parameters. Results: containing carbopol-934 (20%w/w) appeared 99% over 60 min time duration. clarity is homogeneous appearance. Similarly, dissolution studies showed HSD gel’s better rheological properties. content found 96% with improved Keywords: Hydrotropes, dispersion, Solubility, Dissolution, Topical gel, Stability studies.